by E. Hwang

If you’ve been scrolling through your feed lately, you’ve probably seen Kbeauty lovers raving about PDRN, or polydeoxyribonucleotide if you want the full name. It consists of DNA fragments from salmon sperm (there are also plant-based versions) that work like little repair signals for your skin. Originally used in medical settings to help wounds heal faster, this ingredient has made its way into skincare where it boosts collagen production, improves skin texture, reduces fine lines, and gives that coveted glass-skin glow.

While injectable PDRN treatments have been the gold standard in Korean clinics, topical serums bring these benefits home without the needles. Although they don’t penetrate as deeply as injections, they can deliver noticeable improvements in hydration, firmness, and overall skin health over time.

One thing to consider is a products parts per million (ppm). You’ll see concentrations ranging anywhere from 500ppm to 2,000ppm, and while higher sounds better, the sweet spot most dermatologists recommend is actually around 1,000-1,500ppm. That’s the range where clinical studies show optimal results without overwhelming your skin. Anything below 500ppm might be too diluted to make a real difference, while super high concentrations aren’t necessarily more effective since your skin can only absorb so much at once.

So which PDRN serum should you try?

If you want the microneedling-at-home vibe, VT Cosmetics PDRN Reedle Shot 100 ($32) is calling your name. This cult favorite combines vegan PDRN derived from Korean ginseng with tiny spicules that gently exfoliate and help other products absorb better. Just expect a slight tingling sensation at first.

For something more clinical and pharmacy-trusted, CNP Laboratory’s Derma+ Answer Active Boost Ampoule ($20) delivers with its proprietary S-PDRN formulation at 1,200ppm. It’s the kind of serum that feels luxe without being fussy.

And if you’re looking for the OG Korean pharmacy favorite, Dr. Reju-All Advanced PDRN Rejuvenating Cream ($30) is worth the hype. With 99% pure salmon-derived PDRN at 1,200ppm, this formula is lightweight, fast-absorbing, and packed with niacinamide, panthenol, collagen, and hyaluronic acid.

One thing to keep in mind is that PDRN is a marathon ingredient, not a sprint. You won’t see dramatic overnight results, but with consistent use over a few weeks, you’ll notice real improvements in texture, hydration, and that subtle glow that makes people ask what you’re using.